Description

7-Bromo-1-Cyclopropyl-8-(Difluoromethoxy)-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics, a critical class of antimicrobial agents. It is primarily utilized by pharmaceutical R&D departments, fine chemical manufacturers, and academic research institutions engaged in the synthesis of next-generation antibacterial compounds.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of new-generation fluoroquinolone antibiotics.
• Antimicrobial Research: Used in medicinal chemistry programs to develop novel antibacterial agents with improved potency and spectrum of activity.
• Process Chemistry: Serves as a key intermediate in the scale-up and optimization of API (Active Pharmaceutical Ingredient) manufacturing processes.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development and quality control in pharmaceutical production.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) settings for investigating structure-activity relationships (SAR) within the quinolone class.

Basic Information

Product Name	7-Bromo-1-Cyclopropyl-8-(Difluoromethoxy)-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid Ethyl Ester
CAS No.	194805-07-7
Molecular Formula	C₁₆H₁₄BrF₂NO₅
Molecular Weight	418.19 g/mol
Synonyms	Ethyl 7-Bromo-1-cyclopropyl-8-(difluoromethoxy)-1,4-dihydro-4-oxoquinoline-3-carboxylate; 7-Bromo-1-cyclopropyl-8-(difluoromethoxy)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid Ethyl Ester; 194805-07-7; Quinolone Derivative; Fluoroquinolone Intermediate; Difluoromethoxy Quinolone Ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the exacting standards required for pharmaceutical synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We support development and commercial projects requiring compliance with cGMP and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.