Description

4-Bromo-3-Chloro-2-Fluorobenzoic Acid is a high-purity, multi-halogenated benzoic acid derivative serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it a valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores to modulate bioavailability and receptor binding.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the bromo, chloro, and fluoro substituents contribute to biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and organocatalysis.
• Material Science Research: Building block for creating novel organic electronic materials, such as semiconductors or liquid crystals, where halogen atoms fine-tune electronic properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.
• Academic and Industrial R&D: Essential reagent for methodological research in cross-coupling reactions, fluorination chemistry, and other halogen-based transformations.

Basic Information

Product Name	4-Bromo-3-Chloro-2-Fluorobenzoic Acid
CAS No.	194804-94-9
Molecular Formula	C7H3BrClFO2
Molecular Weight	253.45 g/mol
Synonyms	2-Fluoro-4-bromo-3-chlorobenzoic Acid; 3-Chloro-4-bromo-2-fluorobenzoic Acid; Benzoic acid, 4-bromo-3-chloro-2-fluoro-; 4-Bromo-3-chloro-2-fluorobenzoic acid; 194804-94-9; 2-Fluoro-3-chloro-4-bromobenzoic Acid
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Chloro-2-Fluorobenzoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.