Description

2-(4-Bromophenyl)Tetrahydrofuran is a versatile brominated heterocyclic compound that serves as a key synthetic intermediate in advanced organic chemistry. Its value lies in the combination of the tetrahydrofuran ring, which offers polarity and conformational influence, with the 4-bromophenyl group, a classic handle for cross-coupling reactions. This makes it an essential building block for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules via Suzuki, Stille, or other palladium-catalyzed couplings.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders or possessing complex heterocyclic architectures.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the bromine atom facilitates the introduction of other functional groups to modulate biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized phosphine or N-heterocyclic carbene (NHC) ligands used in asymmetric catalysis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, or polymers where the bromophenyl moiety allows for further functionalization and polymerization.
• Cross-Coupling Reactions: Primarily utilized in Suzuki-Miyaura, Stille, and Negishi cross-coupling reactions to form biaryl and other C-C bonds, a fundamental transformation in modern organic synthesis.
• Academic & R&D: A valuable reagent for methodological development and exploring new synthetic pathways in university and corporate research laboratories.

Basic Information

Product Name	2-(4-Bromophenyl)Tetrahydrofuran
CAS No.	194725-15-0
Molecular Formula	C10H11BrO
Molecular Weight	227.10 g/mol
Synonyms	2-(4-Bromophenyl)oxolane; 4-Bromophenyltetrahydrofuran; Tetrahydro-2-(4-bromophenyl)furan; 2-(p-Bromophenyl)tetrahydrofuran; 2-(4-Bromophenyl)THF; 194725-15-0; Oxolane, 2-(4-bromophenyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Bromophenyl)Tetrahydrofuran is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including GC, HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.