Description

Difenyl[(S)-Pyrrolidine-3-Yl]Acetonitrilhydrobromide is a high-purity chiral building block and intermediate of significant value in modern synthetic chemistry. Its primary importance lies in its utility for constructing complex, stereochemically defined molecules, particularly in the pharmaceutical sector. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-quality, enantiomerically pure intermediates for API synthesis and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and neurological disorder targets.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the development of novel chiral ligands and organocatalysts used in enantioselective synthesis.
• Agrochemical Research: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Institutional R&D: Employed in university and research institute laboratories for methodological studies in organic and medicinal chemistry.
• Process Chemistry Development: Utilized for scaling up synthetic routes and optimizing manufacturing processes for chiral compounds under Good Manufacturing Practice (GMP) guidelines.
• Fine Chemical Synthesis: A building block for creating specialty chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Product Name	Difenyl[(S)-Pyrrolidine-3-Yl]Acetonitrilhydrobromide
CAS No.	194602-27-2
Molecular Formula	C19H19N2•HBr or C19H20BrN2
Molecular Weight	357.28 g/mol (for C19H20BrN2)
Synonyms	(S)-2,2-Diphenyl-1-(pyrrolidin-3-yl)acetonitrile Hydrobromide; (S)-α,α-Diphenyl-3-pyrrolidineacetonitrile Hydrobromide; (S)-2,2-Diphenyl-1-(3-pyrrolidinyl)ethanenitrile Hydrobromide; (S)-DPPA-HBr; (S)-Diphenyl(pyrrolidin-3-yl)acetonitrile HBr; (S)-3-(Diphenylcyanomethyl)pyrrolidine Hydrobromide; (S)-1-(Cyanodiphenylmethyl)-3-pyrrolidinol Hydrobromide (tautomeric form).
EINECS	Contact for details

Quality Control

Our Difenyl[(S)-Pyrrolidine-3-Yl]Acetonitrilhydrobromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (S-enantiomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.