Description

3-Iodo-4-(Trifluoromethoxy)Nitrobenzene is a high-purity, multi-functional halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring iodine, trifluoromethoxy, and nitro substituents, makes it a versatile precursor for constructing complex molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group can enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or building block for advanced polymers, liquid crystals, and organic electronic materials requiring specific halogenated aromatic units.
• Cross-Coupling Reactions: The iodine atom is an excellent leaving group for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings, enabling rapid diversification of molecular scaffolds.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for studying biological mechanisms and target engagement.
• Dye and Pigment Intermediate: Acts as a precursor in the synthesis of specialized dyes and pigments where nitro and halogen groups influence color and fastness properties.

Basic Information

Product Name	3-Iodo-4-(Trifluoromethoxy)Nitrobenzene
CAS No.	194344-29-1
Molecular Formula	C7H3F3INO3
Molecular Weight	332.99 g/mol
Synonyms	1-Iodo-2-nitro-4-(trifluoromethoxy)benzene; 2-Nitro-4-(trifluoromethoxy)iodobenzene; 3-Iodo-4-(trifluoromethoxy)-1-nitrobenzene; 4-(Trifluoromethoxy)-3-iodonitrobenzene; Benzene, 1-iodo-2-nitro-4-(trifluoromethoxy)-; Iodo(trifluoromethoxy)nitrobenzene; Nitro(trifluoromethoxy)iodobenzene
EINECS	Contact for details

Quality Control

Our 3-Iodo-4-(Trifluoromethoxy)Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal specifications and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be conducted under appropriate conditions to maintain product integrity.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.