Description

4-Chloro-5,8-Difluoroquinoline-3-Carboxylic Acid Ethyl Ester is a high-value, multi-functional heterocyclic building block critical for advanced organic synthesis. Its core value lies in its versatile reactivity, serving as a key precursor for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce specific quinoline-based pharmacophores.

Application

• Pharmaceutical Intermediate: A crucial synthon for the synthesis of novel fluoroquinolone antibiotics and other bioactive quinoline derivatives.
• Agrochemical Research: Used in developing new generation herbicides and pesticides, leveraging the biological activity of the difluoroquinoline scaffold.
• Material Science: Serves as a building block for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic light-emitting diodes (OLEDs).
• Chemical Synthesis: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) due to the reactive chlorine substituent.
• Dye & Pigment Industry: Acts as a precursor for the synthesis of specialized fluorinated quinoline-based dyes and fluorescent markers.

Basic Information

Product Name	4-Chloro-5,8-Difluoroquinoline-3-Carboxylic Acid Ethyl Ester
CAS No.	193827-70-2
Molecular Formula	C₁₂H₈ClF₂NO₂
Molecular Weight	271.65 g/mol
Synonyms	Ethyl 4-Chloro-5,8-difluoroquinoline-3-carboxylate; 4-Chloro-5,8-difluoro-3-quinolinecarboxylic Acid Ethyl Ester; 5,8-Difluoro-4-chloroquinoline-3-carboxylic Acid Ethyl Ester; 193827-70-2; Quinoline-3-carboxylic acid, 4-chloro-5,8-difluoro-, ethyl ester; Ethyl 4-chloro-5,8-difluoro-3-quinolinecarboxylate
EINECS	Contact for details

Quality Control

Our 4-Chloro-5,8-Difluoroquinoline-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our commitment to quality assurance supports your compliance needs for cGMP, ISO, and other relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.