Description

Acetic Acid, (Dimethoxyphosphinyl)[[(Phenylmethoxy)Carbonyl]Amino]-, Methyl Ester, (S)- (9Ci) is a chiral, organophosphorus compound of significant interest in advanced synthetic chemistry. This high-purity intermediate is critical for the development of enantiomerically pure pharmaceuticals and agrochemicals, where stereochemical control is paramount. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecules with specific biological activity.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of chiral active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of enantiomerically pure herbicides, insecticides, and fungicides to enhance efficacy and reduce environmental impact.
• Peptidomimetic Research: Serves as a phosphonate-containing amino acid derivative for creating protease-resistant peptide analogs and enzyme inhibitors.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis and organocatalysts.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes for studying enzyme function and mechanism.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring high stereochemical fidelity.

Basic Information

Product Name	Acetic Acid, (Dimethoxyphosphinyl)[[(Phenylmethoxy)Carbonyl]Amino]-, Methyl Ester, (S)- (9Ci)
CAS No.	193673-00-6
Molecular Formula	C13H18NO7P
Molecular Weight	331.26 g/mol
Synonyms	(S)-Methyl 2-((((Benzyloxy)carbonyl)amino)(dimethoxyphosphoryl)acetate; (S)-Cbz-Amino(dimethoxyphosphoryl)acetic Acid Methyl Ester; (S)-Methyl N-[(Benzyloxy)carbonyl]amino(dimethoxyphosphoryl)acetate; (S)-Methyl (Cbz-amino)(dimethoxyphosphoryl)acetate; Z-Amino(dimethoxyphosphoryl)acetic Acid Methyl Ester (S-isomer); N-Cbz-α-Aminophosphonoacetic Acid Methyl Ester (S-); Phosphonamidate Derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality management systems. Specifications typically include chiral purity (enantiomeric excess) by chiral HPLC, chemical purity by HPLC, and identity confirmation by NMR and mass spectrometry. Comprehensive Certificates of Analysis (COA) detailing all test results are provided with each shipment. Our quality commitment ensures material suitable for cGMP and non-GMP research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.