Description

4-[4-(Trifluoromethyl)Benzyl]Piperidine Hcl is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its core value lies in the unique trifluoromethyl-benzyl-piperidine scaffold, which is crucial for modulating the pharmacokinetic and binding properties of bioactive molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and metabolic disorder research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme function and receptor interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up production under cGMP conditions.

Basic Information

Product Name	4-[4-(Trifluoromethyl)Benzyl]Piperidine Hydrochloride
CAS No.	193357-81-2
Molecular Formula	C13H16F3N•HCl
Molecular Weight	279.73 g/mol
Synonyms	4-[(4-(Trifluoromethyl)phenyl)methyl]piperidine hydrochloride; 1-[4-(Trifluoromethyl)benzyl]piperidin-4-amine hydrochloride; 4-(4-Trifluoromethylbenzyl)piperidine HCl; Piperidine, 4-[[4-(trifluoromethyl)phenyl]methyl]-, hydrochloride (1:1); 4-(alpha,alpha,α-Trifluoro-p-tolyl)piperidine hydrochloride; 193357-81-2; 4-(4-Trifluoromethyl-benzyl)-piperidine hydrochloride
EINECS	Contact for details

Quality Control

Our 4-[4-(Trifluoromethyl)Benzyl]Piperidine Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with ICH guidelines and meets the stringent requirements for pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.