Description

1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, Tris(1,1-Dimethylethyl) Phenylmethyl Ester is a key protected intermediate in the synthesis of macrocyclic chelating agents. This compound is critically important for the preparation of high-purity DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and its derivatives, which are essential for creating advanced contrast agents and radiopharmaceuticals. It is primarily needed by research institutions, pharmaceutical developers, and fine chemical manufacturers working in medical imaging, targeted radiotherapy, and inorganic chemistry.

Application

• Pharmaceutical Intermediate: A crucial protected precursor for synthesizing DOTA and its bifunctional derivatives used in gadolinium-based MRI contrast agents.
• Radiopharmaceutical Development: Serves as a building block for chelators that bind radioisotopes (e.g., Lutetium-177, Yttrium-90, Gallium-68) for targeted cancer diagnosis and therapy (theranostics).
• Research Chemical: Used in academic and industrial R&D for studying macrocyclic chemistry, complexation kinetics, and metal-ligand interactions.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to create customized chelating scaffolds with specific functionalization for various diagnostic and therapeutic applications.
• Contrast Agent Production: Integral to the manufacturing process of next-generation, high-stability magnetic resonance imaging (MRI) contrast media.

Basic Information

Item	Details
Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, Tris(1,1-Dimethylethyl) Phenylmethyl Ester
CAS No.	192635-89-5
Molecular Formula	C44H68N4O8
Molecular Weight	781.04 g/mol
Synonyms	DOTA-tris(t-butyl ester) benzyl ester; DOTA-tris(t-Bu ester)-Bn ester; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid tris(tert-butyl) benzyl ester; DOTA-tris(O-t-butyl)-O-benzyl ester; Tris(tert-butyl) benzyl DOTA; Macrocyclic chelator protected intermediate; DOTA-tris(tBu)-Bn; 2,2',2''-(10-(Benzyloxy)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid tris(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, Tris(1,1-Dimethylethyl) Phenylmethyl Ester is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.