Description

Mycothiol is a low-molecular-weight thiol compound that serves as the primary redox buffer and detoxification agent in many Actinobacteria, including the genus *Mycobacterium*. This unique biochemical role makes it a critical molecule for research into bacterial physiology and the development of novel therapeutic strategies. It is particularly valuable for scientists investigating oxidative stress responses, antibiotic resistance mechanisms, and potential drug targets in pathogenic species like *M. tuberculosis*. Mycothiol CAS NO 192126-76-4 is therefore an essential research-grade biochemical for academic, pharmaceutical, and diagnostic laboratories worldwide.

Application

• Biochemical Research: Fundamental studies on redox biology and thiol-disulfide balance in Actinobacteria.
• Drug Discovery & Target Validation: Screening and evaluation of compounds designed to inhibit mycothiol biosynthesis or utilization as a novel antibiotic strategy.
• Mechanistic Studies: Investigating detoxification pathways and resistance mechanisms against antibiotics and reactive oxygen/nitrogen species in mycobacteria.
• Enzymology: Serving as a substrate for enzymes such as mycothiol disulfide reductase (Mtr) and mycothiol-S-conjugate amidase (Mca).
• Diagnostic Development: Potential use in assays to detect or quantify bacterial metabolic states.
• Microbiology & Physiology: Understanding the adaptation and survival of mycobacteria under various environmental stresses.

Basic Information

Product Name	Mycothiol
CAS No.	192126-76-4
Molecular Formula	C17H30N2O12S
Molecular Weight	486.49 g/mol
Synonyms	1D-myo-Inosityl 2-(N-Acetyl-L-cysteinyl)amido-2-deoxy-α-D-glucopyranoside; L-Cysteine, N-acetyl-, 1-(1,2-dideoxy-α-D-glucopyranos-2-yl) 1D-myo-inositol ester; MSH; Mycothiol (reduced form); N-Acetyl-1-O-(2-[(N-acetyl-L-cysteinyl)amido]-2-deoxy-α-D-glucopyranosyl)-1D-myo-inositol
EINECS	Contact for details

Quality Control

Our research-grade Mycothiol is produced and handled under strict quality protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (typically ≥95% by HPLC), to ensure consistency and reliability for sensitive research applications. A detailed Certificate of Analysis (COA) is provided, documenting key parameters such as assay, related substances, and residual solvents. We adhere to ISO 9001 quality management principles to guarantee traceability and supply chain integrity.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) and easily oxidized nature, store the product under an inert atmosphere (e.g., argon or nitrogen) at -20°C or below for long-term stability. For short-term use, store desiccated at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.