Description

Ly 379268 is a potent and selective agonist for the metabotropic glutamate receptor subtype 2 (mGluR2). This compound is a critical research tool for investigating the role of glutamatergic signaling in the central nervous system. It is primarily utilized by pharmaceutical researchers and neuroscientists in academic, biotech, and pharmaceutical R&D settings for preclinical studies targeting neurological and psychiatric disorders.

Application

• Neuroscience Research: A key pharmacological agent for studying mGluR2 receptor function and its modulation in neural circuits.
• Psychiatric Disorder Models: Used in preclinical research for conditions such as anxiety, schizophrenia, and addiction to understand potential therapeutic pathways.
• Neuropharmacology Screening: Serves as a reference standard in high-throughput screening assays to discover and validate new central nervous system (CNS) drug candidates.
• Biochemical Assay Development: Employed in the development and calibration of in vitro binding and functional assays for mGluR2.
• Academic & Institutional R&D: Fundamental research tool in university and institutional laboratories focused on glutamate receptor biology and signal transduction.

Basic Information

Product Name	Ly 379268
CAS No.	191471-52-0
Molecular Formula	C19H21N3O4
Molecular Weight	355.39 g/mol
Synonyms	(-)-(1R,4S,5S,6S)-4-Amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid; LY-379268; LY379268; (1R,4S,5S,6S)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide; mGluR2/3 agonist LY379268
EINECS	Contact for details

Quality Control

Our Ly 379268 is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.