Description

(S)-2,2-Dimethyl-4-Bromomethyl-1,3-Dioxane is a high-value chiral building block and versatile alkylating agent, essential for the stereoselective synthesis of complex organic molecules. Its core value lies in providing a protected, reactive bromomethyl handle that enables precise carbon-chain elongation while maintaining the integrity of the sensitive (S)-configured stereocenter. This compound is critically needed by pharmaceutical R&D and process chemistry teams for constructing active pharmaceutical ingredients (APIs), agrochemical intermediates, and advanced materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of chiral herbicides, fungicides, and plant growth regulators requiring specific stereochemistry for bioactivity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in transition metal catalysis.
• Natural Product & Fragrance Synthesis: Employed in the stereocontrolled construction of complex natural product skeletons and chiral fragrance molecules.
• Material Science Monomer: Acts as a functional monomer for introducing chiral centers into polymers and advanced functional materials.
• Academic & Process Research: A valuable tool for methodological development in organic synthesis and scale-up process optimization.

Basic Information

Product Name	(S)-2,2-Dimethyl-4-Bromomethyl-1,3-Dioxane
CAS No.	191354-56-0
Molecular Formula	C7H13BrO2
Molecular Weight	209.08 g/mol
Synonyms	(S)-4-(Bromomethyl)-2,2-dimethyl-1,3-dioxane; (S)-4-Bromomethyl-2,2-dimethyl-1,3-dioxolane (common misnomer); (S)-2,2-Dimethyl-1,3-dioxane-4-bromomethane; (S)-Dioxane Bromomethyl Derivative; (S)-Acetonide Protected Bromoethanol; (S)-1-Bromo-3,3-dimethyl-1,5-dihydroxypentane acetonide; Bromomethyl Dioxane Chiral Building Block
EINECS	Contact for details

Quality Control

Our (S)-2,2-Dimethyl-4-Bromomethyl-1,3-Dioxane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.