Description

2-Amino-5-(Trifluoromethyl)Quinazoline is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique combination of the quinazoline scaffold and the electron-withdrawing trifluoromethyl group, which is critical for modulating the physicochemical properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the CF₃ group can enhance bioavailability and metabolic stability.
• Material Science: Acts as a building block for creating specialized organic ligands and fluorinated polymers with tailored electronic properties.
• Chemical Biology Probe: Utilized in the design of molecular probes and inhibitors to study biological pathways and enzyme functions.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring fluorinated heterocycles.

Basic Information

Product Name	2-Amino-5-(Trifluoromethyl)Quinazoline
CAS No.	190273-74-6
Molecular Formula	C₉H₆F₃N₃
Molecular Weight	213.16 g/mol
Synonyms	5-(Trifluoromethyl)quinazolin-2-amine; 2-Amino-5-(trifluoromethyl)-quinazoline; Quinazoline, 2-amino-5-(trifluoromethyl)-; 190273-74-6; 2-Amino-5-trifluoromethylquinazoline; 5-Trifluoromethyl-2-quinazolinamine
EINECS	Contact for details

Quality Control

Our 2-Amino-5-(Trifluoromethyl)Quinazoline is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming the product meets your specified requirements. For projects requiring regulatory support, we can discuss compliance with relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.