Description

Ethyl 2-(8-Hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)acetate is a high-value, multifunctional spirocyclic building block and chiral intermediate essential for advanced organic synthesis. This compound matters because its unique structure, featuring a protected diol and an ester-functionalized side chain, provides a versatile handle for constructing complex molecules with precise stereochemistry. Pharmaceutical, agrochemical, and specialty chemical R&D teams need it for the development of novel active ingredients, particularly in the synthesis of prostaglandins, macrolides, and other bioactive compounds where its spiroketal moiety is a critical structural motif.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of prostaglandin analogs and other potent bioactive molecules.
• Agrochemical Synthesis: Used in the development of advanced fungicides and plant growth regulators that require specific stereochemistry.
• Fine Chemical Building Block: Serves as a versatile precursor for synthesizing complex natural products, fragrances, and specialty polymers.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the development of new catalytic systems for stereoselective transformations.
• Material Science: Potential monomer for creating novel polymers with unique thermal and mechanical properties derived from the spirocyclic core.

Basic Information

Product Name	Ethyl 2-(8-Hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)acetate
CAS No.	189509-22-6
Molecular Formula	C13H22O5
Molecular Weight	258.31 g/mol
Synonyms	8-Hydroxy-1,4-dioxaspiro[4.5]decane-8-acetic acid ethyl ester; Ethyl (8-hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)acetate; 1,4-Dioxaspiro[4.5]decan-8-ol, 8-acetic acid ethyl ester; Spiroketal Ethyl Acetate Derivative; Prostaglandin Intermediate F2; 189509-22-6
EINECS	Contact for details

Quality Control

Our Ethyl 2-(8-Hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)acetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided to guarantee traceability, consistency, and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled and stored away from strong acids and organic solvents to maintain stability. Keep the container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.