Description

5-(Difluoromethyl)Thiophene-2-Carboxylic Acid is a high-value, multi-functional heterocyclic building block characterized by its carboxylic acid group and difluoromethyl substituent on the thiophene ring. This compound is essential for introducing the metabolically stable difluoromethyl group and the versatile carboxylic acid handle into target molecules, enabling precise structural modifications. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including kinase inhibitors and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor programs and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance bioavailability and stability.
• Material Science Research: Serves as a monomer or precursor for functional polymers and advanced organic electronic materials due to the thiophene backbone.
• Ligand and Catalyst Development: Employed in creating novel ligands for metal catalysis or as a component in organocatalysts.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical manufacturing.

Basic Information

Product Name	5-(Difluoromethyl)Thiophene-2-Carboxylic Acid
CAS No.	189330-23-2
Molecular Formula	C6H4F2O2S
Molecular Weight	178.16 g/mol
Synonyms	2-Thiophenecarboxylic acid, 5-(difluoromethyl)-; 5-(Difluoromethyl)-2-thiophenecarboxylic acid; 5-(Difluoromethyl)thiophene-2-carboxylic acid; 2-Carboxy-5-(difluoromethyl)thiophene; 189330-23-2; 5-Difluoromethylthiophene-2-carboxylic acid; Thiophene-2-carboxylic acid, 5-(difluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 5-(Difluoromethyl)Thiophene-2-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment. Our quality protocols are designed to support cGMP compliance for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.