Description

n-(3-Iodophenyl)-6,7-Dimethoxyquinazolin-4-Amine is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of heterocyclic compounds. This compound is of significant commercial interest for its role as a key building block in the synthesis of targeted therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs, particularly kinase inhibitors. The product is supplied with a Certificate of Analysis to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted kinase inhibitors for oncology and other therapeutic areas.
• Biochemical Research: Used as a reference standard or a probe molecule in enzymatic assays and structure-activity relationship (SAR) studies.
• Drug Discovery & Development: Serves as a core scaffold for medicinal chemists to design and optimize new chemical entities with potential biological activity.
• Academic Research: Employed in university and institutional labs for studying quinazoline chemistry and its pharmacological applications.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations for custom synthesis projects under cGMP or non-GMP conditions.

Basic Information

Product Name	n-(3-Iodophenyl)-6,7-Dimethoxyquinazolin-4-Amine
CAS No.	189290-58-2
Molecular Formula	C₁₆H₁₄IN₃O₂
Molecular Weight	407.21 g/mol
Synonyms	6,7-Dimethoxy-N-(3-iodophenyl)quinazolin-4-amine; 4-Amino-6,7-dimethoxy-N-(3-iodophenyl)quinazoline; N-(3-Iodophenyl)-6,7-dimethoxy-4-quinazolinamine; 189290-58-2; 6,7-Dimethoxy-N-(3-iodophenyl)-4-quinazolinamine
EINECS	Contact for details

Quality Control

Our n-(3-Iodophenyl)-6,7-Dimethoxyquinazolin-4-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. For custom synthesis projects, we can align our QC protocols with specific client requirements or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.