Description

3-Quinolinecarboxylic Acid, 1-(6-Amino-3,5-Difluoro-2-Pyridinyl)-8-Chloro-6,7-Difluoro-1,4-Dihydro-4-Oxo-, Ethyl Ester is a high-purity, complex heterocyclic compound designed for advanced pharmaceutical research and synthesis. This molecule serves as a critical advanced pharmaceutical intermediate, particularly valued for its role in the development of novel fluoroquinolone antibiotics and other active pharmaceutical ingredients (APIs). It is essential for R&D chemists and process development scientists in the pharmaceutical and fine chemical industries who require reliable, high-quality building blocks for complex molecular construction.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of next-generation fluoroquinolone antibiotic candidates.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for novel antibacterial agents.
• Chemical Research: Serves as a sophisticated scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for complex heterocyclic compounds.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-(6-Amino-3,5-Difluoro-2-Pyridinyl)-8-Chloro-6,7-Difluoro-1,4-Dihydro-4-Oxo-, Ethyl Ester
CAS No.	189279-51-4
Molecular Formula	C₁₈H₁₁ClF₄N₃O₃
Molecular Weight	428.75 g/mol
Synonyms	Ethyl 1-(6-Amino-3,5-difluoropyridin-2-yl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate; 1-(6-Amino-3,5-difluoro-2-pyridinyl)-8-chloro-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester; ABT-492 Intermediate; ZABTIQ Intermediate; WCK 771 Intermediate; DX-619 Intermediate; 189279-51-4; Ethyl 8-chloro-6,7-difluoro-1-(6-amino-3,5-difluoro-2-pyridyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for pharmaceutical research. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring traceability and consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability. Keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.