Description

Fmoc-Dap(Alloc)-Oh CAS NO 188970-92-5 is a protected amino acid derivative, specifically an Fmoc- and Alloc-protected derivative of L-2,3-diaminopropionic acid, serving as a critical building block in solid-phase peptide synthesis (SPPS). Its value lies in enabling the orthogonal deprotection of side-chain and backbone functionalities, allowing for the precise and complex assembly of peptides, including cyclic and branched structures. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require reliable, high-quality reagents for constructing challenging peptide sequences.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, facilitating the incorporation of a diamino acid with orthogonal protecting groups.
• Pharmaceutical Intermediate: Used in the research and development of novel therapeutic peptides, including antimicrobial peptides and hormone analogs.
• Conjugation and Linker Chemistry: The Alloc-protected side-chain amine is ideal for selective deprotection and subsequent conjugation to labels, tags, or solid supports.
• Synthesis of Cyclic Peptides: Enables the construction of peptide macrocycles by providing differentiated amino groups for ring-closing reactions.
• Bioconjugation and Protein Engineering: Serves as a specialized building block for introducing unique chemical handles into synthetic peptides for further bioconjugation.
• Combinatorial Library Development: A valuable component in creating diverse peptide libraries for drug discovery and screening applications.

Basic Information

Product Name	Fmoc-Dap(Alloc)-Oh
CAS No.	188970-92-5
Molecular Formula	C22H22N2O6
Molecular Weight	410.42 g/mol
Synonyms	Fmoc-L-2,3-diaminopropionic acid(Alloc)-OH; Nα-Fmoc-Nβ-Alloc-L-2,3-diaminopropionic acid; Fmoc-Dap(Alloc)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-[(2-propen-1-yloxy)carbonylamino]propanoic acid; N-Alloc-N'-Fmoc-L-2,3-diaminopropionic acid; Fmoc-Dap(Alloc)-OH; Fmoc-Dap(Alloc)
EINECS	Contact for details

Quality Control

Our Fmoc-Dap(Alloc)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical and pharmaceutical intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.