Description

4-Maleimidophenylacetic Acid Hydrazide is a heterobifunctional crosslinking agent featuring both a maleimide group and a hydrazide moiety. This compound is critical for creating stable, site-specific conjugations between biomolecules, such as antibodies, peptides, and oligonucleotides, and various surfaces or other molecules. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, diagnostics, and targeted drug delivery development.

Application

• Bioconjugation Reagent: For site-specific coupling of peptides, proteins, or antibodies to carriers, surfaces, or other biomolecules via the maleimide-thiol and hydrazide-carbonyl chemistries.
• ADC (Antibody-Drug Conjugate) Development: As a key linker component for attaching cytotoxic payloads to monoclonal antibodies, enabling targeted cancer therapies.
• Diagnostic Assay Development: For immobilizing capture antibodies or antigens onto sensor surfaces, microplates, or nanoparticles in ELISA, lateral flow, and other immunoassay formats.
• Polymer and Material Science: Used to functionalize polymers, hydrogels, or nanomaterials with bioactive ligands for tissue engineering or biosensing applications.
• Protein Labeling and Modification: For introducing tags, fluorophores, or other probes onto specific sites of proteins for imaging, tracking, or functional studies.
• Carbohydrate and Glycoprotein Labeling: The hydrazide group selectively reacts with oxidized sugar aldehydes, enabling the study and targeting of glycans.

Basic Information

Product Name	4-Maleimidophenylacetic Acid Hydrazide
CAS No.	188944-35-6
Molecular Formula	C13H13N3O3
Molecular Weight	259.26 g/mol
Synonyms	4-(Maleimidomethyl)phenylacetic acid hydrazide; 4-Maleimidophenylacetic hydrazide; 4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenylacetic acid hydrazide; 1-[4-(Hydrazinecarbonylmethyl)phenyl]-1H-pyrrole-2,5-dione; MPAAH; 4-Maleimidobenzeneacetic acid hydrazide; Maleimidophenylacetic hydrazide
EINECS	Contact for details

Quality Control

Our 4-Maleimidophenylacetic Acid Hydrazide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and performance. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.