Description

1-Piperidinecarboxylic Acid, 4-Cyano-3-Hydroxy-, 1,1-Dimethylethyl Ester, trans- is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and production of innovative drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, especially in central nervous system (CNS) and metabolic disorder research.
• Protease Inhibitor Synthesis: Serves as a precursor in the development of specific protease inhibitors due to its piperidine and cyano-hydroxy motifs.
• Chemical Research & Development: Used in academic and industrial R&D for exploring new chemical entities and reaction pathways in medicinal chemistry.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke, multi-step synthetic routes for clients.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 4-Cyano-3-Hydroxy-, 1,1-Dimethylethyl Ester, trans-
CAS No.	188879-53-0
Molecular Formula	C12H20N2O3
Molecular Weight	240.30 g/mol
Synonyms	trans-4-Cyano-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl (3R,4R)-4-cyano-3-hydroxypiperidine-1-carboxylate; (3R,4R)-1-Boc-4-cyano-3-hydroxypiperidine; (3R,4R)-4-Cyano-3-hydroxypiperidine-1-carboxylic acid tert-butyl ester; 1-Boc-4-cyano-3-hydroxypiperidine (trans); trans-1-N-Boc-4-cyano-3-hydroxypiperidine; (3R,4R)-1-(tert-Butoxycarbonyl)-4-cyano-3-hydroxypiperidine
EINECS	Contact for details

Quality Control

Our 1-Piperidinecarboxylic Acid, 4-Cyano-3-Hydroxy-, 1,1-Dimethylethyl Ester, trans- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and identification via spectroscopic methods. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.