Description

(2S)-2-(1-Ethoxyethoxy)-1,4-Butanediol is a chiral, protected diol derivative of significant interest in advanced organic synthesis. Its core value proposition lies in its role as a versatile chiral building block and protecting group intermediate for the production of complex, optically active molecules. This compound is particularly needed by research and development chemists and process development scientists in the pharmaceutical and fine chemical industries. It enables the stereoselective synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and other high-value specialty chemicals.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key building block for the stereoselective construction of complex drug molecules, particularly those requiring specific (S)-configuration at the carbon center.
• Protecting Group Chemistry: The 1-ethoxyethyl (EE) protecting group on the secondary alcohol allows for selective manipulation of the primary hydroxyl group during multi-step syntheses.
• Asymmetric Catalysis & Ligand Synthesis: Used in the preparation of chiral ligands, auxiliaries, and catalysts for enantioselective transformations.
• Fine Chemical and Agrochemical Production: Serves as a precursor for the synthesis of specialty chemicals, advanced materials, and chiral agrochemicals.
• Academic and Industrial R&D: A valuable reagent for method development and exploring new synthetic routes in organic chemistry laboratories.

Basic Information

Product Name	(2S)-2-(1-Ethoxyethoxy)-1,4-Butanediol
CAS No.	188790-85-4
Molecular Formula	C8H18O4
Molecular Weight	178.23 g/mol
Synonyms	(S)-2-(1-Ethoxyethoxy)-1,4-butanediol; (2S)-2-(1-Ethoxyethoxy)butane-1,4-diol; 1,4-Butanediol, 2-(1-ethoxyethoxy)-, (2S)-; EE-protected (S)-1,2,4-butanetriol; (S)-1,2,4-Butanetriol 1-(1-ethoxyethyl) ether; Chiral EE-protected butanediol; (S)-2-(EEO)-1,4-butanediol
EINECS	Contact for details

Quality Control

Our (2S)-2-(1-Ethoxyethoxy)-1,4-Butanediol is produced under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive analytical data, including chiral purity (enantiomeric excess) and chemical assay, verified by techniques such as HPLC, GC, and NMR. Certificates of Analysis (COA) detailing all specifications are available for every batch upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.