Description

4H-1,3-Dioxolo4,5-Cpyrrole, 4-(4-Bromophenyl)-6-(1,1-Dimethylethyl)Dimethylsilyloxymethyltetrahydro-2,2-Dimethyl-, (3As,4S,6R,6Ar)- is a high-value, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D and manufacturing organizations engaged in developing novel therapeutics.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Organic Synthesis Building Block: Used in advanced organic chemistry research and process development for constructing fused heterocyclic systems.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Process Chemistry: Employed in the development and scale-up of synthetic routes for target molecules requiring this specific stereochemistry and functionalization.
• Contract Manufacturing (CMO/CDMO): Supplied to contract research and manufacturing organizations for custom synthesis projects.

Basic Information

Item	Details
Product Name	4H-1,3-Dioxolo4,5-Cpyrrole, 4-(4-Bromophenyl)-6-(1,1-Dimethylethyl)Dimethylsilyloxymethyltetrahydro-2,2-Dimethyl-, (3As,4S,6R,6Ar)-
CAS No.	188744-83-4
Molecular Formula	C21H32BrNO3Si
Molecular Weight	454.48 g/mol
Synonyms	(3aS,4S,6R,6aR)-4-(4-Bromophenyl)-6-[[(tert-Butyldimethylsilyl)oxy]methyl]tetrahydro-2,2-dimethyl-4H-[1,3]dioxolo[4,5-c]pyrrole; tert-Butyldimethyl((3aS,4S,6R,6aR)-4-(4-bromophenyl)-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrol-6-yl)methoxy)silane; 4-(4-Bromophenyl)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrole; (3aS,4S,6R,6aR)-4-(4-Bromophenyl)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrole; TBS-protected bromophenyl dioxolopyrrole intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested to ensure identity, purity, and stereochemical integrity, with specifications tailored to client requirements. A comprehensive Certificate of Analysis (COA) detailing results for assay, chiral purity, and related substances is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.