Description

1-Acetyl-3-[((2R)-1-Methylpyrrolidin-2-Yl)Methyl]-5-[(E)-2-(Phenylsulfonyl)Vinyl]Indole is a sophisticated chiral indole derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound matters as a key synthetic intermediate or a potential pharmacophore, offering a unique structural scaffold for developing novel bioactive molecules. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries for applications in medicinal chemistry, process development, and the synthesis of complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of potential drug candidates, particularly those targeting neurological or oncological pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Asymmetric Synthesis: Utilized in chiral synthesis due to its inherent (R)-configured pyrrolidine moiety, enabling the construction of enantiomerically pure compounds.
• Fine Chemical Production: Acts as a precursor in the multi-step synthesis of complex, high-value specialty chemicals and advanced materials.
• Biochemical Probe Development: Potential use in designing molecular probes for studying biological systems and enzyme interactions.

Basic Information

Product Name	1-Acetyl-3-[((2R)-1-Methylpyrrolidin-2-Yl)Methyl]-5-[(E)-2-(Phenylsulfonyl)Vinyl]Indole
CAS No.	188113-71-5
Molecular Formula	C25H28N2O3S
Molecular Weight	436.57 g/mol
Synonyms	1-Acetyl-3-[(1-methyl-2-pyrrolidinyl)methyl]-5-[(E)-2-(phenylsulfonyl)ethenyl]-1H-indole; (R)-1-Acetyl-3-((1-methylpyrrolidin-2-yl)methyl)-5-((E)-2-(phenylsulfonyl)vinyl)-1H-indole; 1H-Indole, 1-acetyl-3-[(1-methyl-2-pyrrolidinyl)methyl]-5-[(E)-2-(phenylsulfonyl)ethenyl]-; 188113-71-5; (R)-enantiomer of the indole sulfone derivative
EINECS	Contact for details

Quality Control

Our 1-Acetyl-3-[((2R)-1-Methylpyrrolidin-2-Yl)Methyl]-5-[(E)-2-(Phenylsulfonyl)Vinyl]Indole is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.