Description

3-Amino-5-(4-Chlorophenyl)-2-Thiophenecarboxylic Acid is a high-purity, multifunctional heterocyclic building block of significant commercial and research interest. Its core value lies in its versatile molecular structure, which serves as a critical intermediate in the synthesis of complex, biologically active molecules. This compound is essential for pharmaceutical R&D teams, agrochemical manufacturers, and advanced material scientists seeking to develop novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides, leveraging its thiophene and chlorophenyl motifs.
• Material Science Research: Serves as a building block for creating novel organic semiconductors, conductive polymers, and non-linear optical (NLO) materials.
• Chemical Biology & Proteomics: Employed as a scaffold or linker in the design of molecular probes, enzyme inhibitors, and activity-based protein profiling (ABPP) reagents.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized dyes and pigments where the thiophene core contributes to color fastness and unique chromatic properties.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom chemical synthesis (CDMO) services catering to the fine chemical and life science industries.

Basic Information

Product Name	3-Amino-5-(4-Chlorophenyl)-2-Thiophenecarboxylic Acid
CAS No.	187949-86-6
Molecular Formula	C11H8ClNO2S
Molecular Weight	253.70 g/mol
Synonyms	5-(4-Chlorophenyl)-3-amino-2-thiophenecarboxylic acid; 3-Amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid; 2-Thiophenecarboxylic acid, 3-amino-5-(4-chlorophenyl)-; 3-Amino-5-(p-chlorophenyl)thiophene-2-carboxylic acid; 187949-86-6; AKOS BRN 0972; A1-03495; SCHEMBL11827679; CTK8G7125
EINECS	Contact for details

Quality Control

Every batch of 3-Amino-5-(4-Chlorophenyl)-2-Thiophenecarboxylic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency meet the stringent requirements of our global clientele. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your quality assurance and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.