Description

(-)-1,2(2R,5R)-2,5-(Dimethylphospholano)Benzene(Cyclooctadiene)Rhodium(I)Trifluoromethanesulfonate CAS NO 187682-63-9 is a high-purity, chiral organorhodium complex widely recognized for its exceptional catalytic properties. This compound is a critical component in advanced asymmetric synthesis, enabling the production of enantiomerically pure intermediates essential for pharmaceuticals and fine chemicals. It is primarily sought after by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical sectors for developing and scaling up high-value chiral products.

Application

• Asymmetric Hydrogenation Catalysis: A premier catalyst for the enantioselective hydrogenation of prochiral olefins, enamides, and ketones in pharmaceutical intermediate synthesis.
• Chiral Active Pharmaceutical Ingredient (API) Manufacturing: Used in the critical steps for producing enantiomerically pure drugs, including antibiotics, cardiovascular agents, and central nervous system therapeutics.
• Fine Chemical Synthesis: Enables the asymmetric synthesis of complex chiral molecules for fragrances, flavors, and advanced materials.
• Agrochemical Intermediate Production: Applied in the creation of chiral herbicides, fungicides, and plant growth regulators with enhanced efficacy and environmental profile.
• Academic and Industrial R&D: Serves as a key reagent for methodological development in organic chemistry and process optimization studies.
• Ligand Screening and Catalyst Development: Used as a benchmark or precursor in the development of new chiral phosphine-rhodium catalytic systems.

Basic Information

Product Name	(-)-1,2(2R,5R)-2,5-(Dimethylphospholano)Benzene(Cyclooctadiene)Rhodium(I)Trifluoromethanesulfonate
CAS No.	187682-63-9
Molecular Formula	C₁₉H₂₇F₃O₃P Rh S
Molecular Weight	529.35 g/mol
Synonyms	(-)-[Rh((R,R)-Me-DuPhos)(COD)]OTf; (R,R)-Me-DuPhos Rhodium(I) Triflate; (R,R)-(-)-1,2-Bis(2,5-dimethylphospholano)benzene(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; Rh-(R,R)-Me-DuPhos-COD-OTf; [Rh(COD)((R,R)-Me-DuPhos)]OTf; (R,R)-Me-DuPhos-Rh-COD-OTf; DuPhos Rhodium Catalyst; Asymmetric Hydrogenation Catalyst (Me-DuPhos Rhodium Complex)
EINECS	Contact for details

Quality Control

Our (-)-1,2(2R,5R)-2,5-(Dimethylphospholano)Benzene(Cyclooctadiene)Rhodium(I)Trifluoromethanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and elemental analysis, to ensure high chemical and chiral purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry place. This material is moisture-sensitive and easily oxidized; ensure containers are sealed immediately after use to minimize exposure to air and humidity.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline solid or powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Rhodium Content	19.0 - 20.5 %
Solubility	Soluble in dichloromethane, acetone; sparingly soluble in toluene

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.