Description

(3As,6As)-Tetrahydro-1H-Cyclopenta[C]Furan-5(3H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique bicyclic furanone structure. This compound is of significant commercial value for its role as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of novel therapeutic agents, particularly in areas requiring stereochemical control.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Asymmetric Synthesis: Used as a starting material or precursor in catalytic asymmetric reactions to introduce specific stereocenters into target molecules.
• Medicinal Chemistry Research: Serves as a versatile scaffold in drug discovery programs for constructing and optimizing novel chemical entities with potential biological activity.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for API manufacturing, where consistent quality and purity are paramount.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals, flavors, and fragrances that require high stereochemical purity.

Basic Information

Product Name	(3As,6As)-Tetrahydro-1H-Cyclopenta[C]Furan-5(3H)-One
CAS No.	187528-23-0
Molecular Formula	C7H8O2
Molecular Weight	124.14 g/mol
Synonyms	(3aR,6aR)-Tetrahydro-1H-cyclopenta[c]furan-5(3H)-one; (3aR,6aR)-Hexahydro-1H-cyclopenta[c]furan-5-one; (3aR,6aR)-5-Oxohexahydro-1H-cyclopenta[c]furan; (R,R)-Tetrahydro-1H-cyclopenta[c]furan-5(3H)-one; Chiral Cyclopentafuranone; Bicyclic Furanone Intermediate
EINECS	Contact for details

Quality Control

Our (3As,6As)-Tetrahydro-1H-Cyclopenta[C]Furan-5(3H)-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.