Description

(5S)-5-(((Tetrahydro-2H-Pyran-2-Yl)Oxy)Methyl)Dihydrofuran-2(3H)-One is a high-value chiral building block and protected lactone derivative, essential for the synthesis of complex pharmaceutical intermediates. Its core value lies in providing a stereochemically defined scaffold that enables the efficient construction of biologically active molecules with precise three-dimensional architecture. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in developing novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and anti-inflammatory drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Antiviral Drug Research: Used as a building block for nucleoside and nucleotide analogs, which are crucial in developing treatments for viral infections.
• Protease Inhibitor Synthesis: Serves as a precursor in the construction of protease inhibitors, a major class of therapeutics.
• Asymmetric Synthesis: Exploited in stereoselective reactions to introduce the (5S) configuration into target molecules, ensuring high enantiomeric purity.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing for producing high-value specialty chemicals.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry programs and process development in both academic and industrial research laboratories.

Basic Information

Item	Details
Product Name	(5S)-5-(((Tetrahydro-2H-Pyran-2-Yl)Oxy)Methyl)Dihydrofuran-2(3H)-One
CAS No.	187264-97-7
Molecular Formula	C10H16O4
Molecular Weight	200.23 g/mol
Synonyms	(5S)-5-((Tetrahydro-2H-pyran-2-yloxy)methyl)dihydrofuran-2(3H)-one; (5S)-5-((Tetrahydro-2H-pyran-2-yloxy)methyl)tetrahydrofuran-2-one; (S)-5-((Tetrahydro-2H-pyran-2-yloxy)methyl)dihydrofuran-2(3H)-one; (S)-5-((Tetrahydro-2H-pyran-2-yloxy)methyl)tetrahydrofuran-2-one; THP-protected (S)-5-hydroxymethyl butyrolactone; (S)-5-(Tetrahydro-2H-pyran-2-yloxymethyl)dihydrofuran-2(3H)-one; (S)-5-(Tetrahydro-2H-pyran-2-yloxymethyl)tetrahydrofuran-2-one
EINECS	Contact for details

Quality Control

Our (5S)-5-(((Tetrahydro-2H-Pyran-2-Yl)Oxy)Methyl)Dihydrofuran-2(3H)-One is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure compliance with the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, identity, and chiral purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.