Description

2-(Bromodifluoromethyl)-1,3-Benzoxazole is a specialized heterocyclic building block featuring a reactive bromodifluoromethyl group. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists working on fluorinated active ingredients and advanced materials. The unique combination of the benzoxazole scaffold and the difluoromethyl moiety makes it a versatile synthon for introducing fluorine atoms into target structures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of fluorinated drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the difluoromethyl group can enhance biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for developing fluorinated polymers, liquid crystals, or organic electronic materials with tailored properties.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to create more complex biaryl structures.
• Fluorine Chemistry Studies: Employed in academic and industrial laboratories to study new methodologies for incorporating CF2 groups into heterocyclic systems.

Basic Information

Product Name	2-(Bromodifluoromethyl)-1,3-Benzoxazole
CAS No.	186828-50-2
Molecular Formula	C8H4BrF2NO
Molecular Weight	248.03 g/mol
Synonyms	2-(Bromodifluoromethyl)benzoxazole; 1,3-Benzoxazole, 2-(bromodifluoromethyl)-; Benzoxazole, 2-(bromodifluoromethyl)-; 2-(Bromodifluoromethyl)-1,3-benzoxazole; 186828-50-2; 2-Bromodifluoromethylbenzoxazole
EINECS	Contact for details

Quality Control

Our 2-(Bromodifluoromethyl)-1,3-Benzoxazole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as identity, assay, and impurity profiles. Our quality system is designed to support cGMP compliance for advanced intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.