Description

n-Fmoc-5-Amino-2-Chlorobenzoic Acid CAS NO 186320-16-1 is a protected amino acid derivative, specifically an ortho-chlorinated benzoic acid with an Fmoc-protected amine group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of modified aromatic amino acid residues into peptide chains. It is primarily utilized by pharmaceutical researchers, peptide manufacturers, and biotechnology companies for the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid precursor for incorporating 5-amino-2-chlorobenzoic acid motifs into custom peptide sequences.
• Pharmaceutical Intermediate: For the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs) targeting various diseases.
• Bioconjugation & Probe Development: Used to synthesize fluorescent or affinity-labeled peptides for biochemical assays, imaging, and diagnostic applications.
• Combinatorial Chemistry Libraries: Serves as a versatile building block for creating diverse chemical libraries in drug discovery programs.
• Material Science & Specialty Polymers: Potential use in the synthesis of functionalized polymers and advanced materials with specific aromatic functionalities.

Basic Information

Product Name	n-Fmoc-5-Amino-2-Chlorobenzoic Acid
CAS No.	186320-16-1
Molecular Formula	C22H16ClNO4
Molecular Weight	393.82 g/mol
Synonyms	5-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-2-chlorobenzoic Acid; 2-Chloro-5-[(9H-fluoren-9-ylmethoxy)carbonylamino]benzoic Acid; Fmoc-5-Amino-2-Chlorobenzoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-amino-2-chlorobenzoic Acid; 5-(Fmoc-amino)-2-chlorobenzoic Acid; 2-Chloro-5-(Fmoc-amino)benzoic Acid; 186320-16-1; N-Fmoc-2-chloro-5-aminobenzoic acid
EINECS	Contact for details

Quality Control

Our n-Fmoc-5-Amino-2-Chlorobenzoic Acid is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere (e.g., nitrogen or argon) after each use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.