Description

n-Fmoc-4-Amino-2-Chlorobenzoic Acid is a key protected amino acid derivative used as a sophisticated building block in organic synthesis. This compound is critically important for the controlled introduction of a functionalized benzoic acid moiety in complex molecular architectures. It is primarily required by research and development laboratories in the pharmaceutical and biotechnology sectors for applications in peptide synthesis and medicinal chemistry.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a crucial Fmoc-protected amino acid component for the incorporation of a chlorinated, aromatic amino acid residue into peptide chains.
• Medicinal Chemistry & Drug Discovery: Used as a versatile intermediate in the design and synthesis of novel drug candidates, particularly for creating targeted libraries and structure-activity relationship (SAR) studies.
• Bioconjugation: Acts as a linker or functional handle for attaching peptides or other molecules to surfaces, polymers, or biomolecules via its carboxylic acid group.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes and labeled compounds for studying biological processes and enzyme functions.
• Custom Oligomer Synthesis: A valuable building block for research institutions and CROs (Contract Research Organizations) specializing in the production of non-standard peptides and peptidomimetics.

Basic Information

Product Name	n-Fmoc-4-Amino-2-Chlorobenzoic Acid
CAS No.	186320-13-8
Molecular Formula	C22H16ClNO4
Molecular Weight	393.82 g/mol
Synonyms	Fmoc-4-Amino-2-chlorobenzoic Acid; 2-Chloro-4-[(9H-fluoren-9-ylmethoxy)carbonyl]aminobenzoic Acid; 4-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-2-chlorobenzoic Acid; 4-(Fmoc-amino)-2-chlorobenzoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-amino-2-chlorobenzoic Acid; 2-Chloro-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]benzoic Acid; Fmoc-2-Cl-4-Abz-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-4-Amino-2-Chlorobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.