Description

2-(1'-(tert-Butoxycarbonyl)-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-3-Yl)Acetic Acid is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and piperidine scaffold. This compound is critical for research and development in medicinal chemistry, serving as a key building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting neurological and central nervous system disorders. The product is supplied with stringent quality control to ensure batch-to-batch consistency for demanding synthetic applications.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug candidates, particularly those targeting receptor modulation.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Synthesis: Serves as a building block for the final construction of Active Pharmaceutical Ingredients (APIs) with spirocyclic architectures.
• Neurological Drug Development: Applied in the research of potential therapeutics for conditions such as depression, anxiety, and cognitive disorders due to its piperidine moiety.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of target molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.

Basic Information

Product Name	2-(1'-(tert-Butoxycarbonyl)-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-3-Yl)Acetic Acid
CAS No.	185526-66-3
Molecular Formula	C20H25NO4
Molecular Weight	343.42 g/mol
Synonyms	2-[1-[(2-Methylpropan-2-yl)oxycarbonyl]-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl]acetic acid; 2-(1-Boc-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid; 3-Carboxymethyl-1-Boc-1,2-dihydrospiro[3H-indene-1,4'-piperidine]; 1-Boc-3-carboxymethyl-1,2-dihydrospiro[3H-indene-1,4'-piperidine]; tert-Butyl 3-(carboxymethyl)-2,3-dihydro-1H-spiro[indene-1,4'-piperidine]-1'-carboxylate; BOC-Spiroindane-piperidine Acetic Acid; CAS 185526-66-3.
EINECS	Contact for details

Quality Control

Our 2-(1'-(tert-Butoxycarbonyl)-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-3-Yl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) documenting all critical parameters are provided to ensure traceability and compliance with your internal quality standards and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.