Description

1,3-Dihydrospiro[Indene-2,4'-Piperidine]-1-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic structure. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders.
• Organic Synthesis Building Block: Utilized in research and development for constructing novel spirocyclic and heterocyclic compounds with potential biological activity.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in early-stage drug discovery programs.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals requiring high structural fidelity and purity.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production of clinical trial materials.

Basic Information

Product Name	1,3-Dihydrospiro[Indene-2,4'-Piperidine]-1-One
CAS No.	185525-49-9
Molecular Formula	C13H15NO
Molecular Weight	201.27 g/mol
Synonyms	Spiro[indene-2,4'-piperidin]-1(3H)-one; 1,3-Dihydro-2H-spiro[indene-2,4'-piperidine]-1-one; 1-Oxo-1,3-dihydrospiro[indene-2,4'-piperidine]; 185525-49-9; Spiro[indene-2,4'-piperidin]-1-one
EINECS	Contact for details

Quality Control

Our 1,3-Dihydrospiro[Indene-2,4'-Piperidine]-1-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.