Description

Doyle Dirhodium Catalyst - Rh2(4S-Mppim)4 is a highly specialized chiral dirhodium(II) carboxylate complex, a cornerstone in modern asymmetric synthesis. Its value lies in its exceptional ability to catalyze enantioselective carbenoid transformations, such as cyclopropanations and C-H insertions, with high stereocontrol. This catalyst is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel, single-enantiomer compounds efficiently.

Application

• Asymmetric Cyclopropanation: Key for constructing chiral three-membered carbocycles, vital intermediates in active pharmaceutical ingredients (APIs).
• Enantioselective C-H Functionalization: Enables direct, stereocontrolled insertion into C-H bonds, streamlining synthetic routes.
• Synthesis of Chiral Building Blocks: For the production of enantiopure intermediates used in drug discovery and development.
• Pharmaceutical Intermediate Manufacturing: Critical in the scalable synthesis of complex, stereochemically defined molecules.
• Methodology Development in Academic & Industrial R&D: A standard tool for developing new catalytic asymmetric reactions.
• Agrochemical Synthesis: For creating enantiomerically pure herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.

Basic Information

Product Name	Doyle Dirhodium Catalyst - Rh2(4S-Mppim)4
CAS No.	185437-81-4
Molecular Formula	C52H44N8O8Rh2
Molecular Weight	1123.78 g/mol
Synonyms	Dirhodium(II) tetrakis[(4S)-(-)-1-(4-methylphenyl)-3-methyl-4-phenyl-4,5-dihydro-1H-pyrazol-5-onato]; Rh2(4S-MPPIM)4; Rh2(S-MPPIM)4; (S)-Dirhodium(II) MPPIM Catalyst; Doyle Catalyst; Dirhodium(II) (S)-MPPIM complex; Tetrakis[μ-[(4S)-1-(4-methylphenyl)-3-methyl-4-phenyl-4,5-dihydro-1H-pyrazol-5-onato]]dirhodium
EINECS	Contact for details

Quality Control

Every batch of our Doyle Dirhodium Catalyst is manufactured and tested under strict quality management systems to ensure consistent, high-performance material. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chiral purity (enantiomeric excess), Rh content, and solvent residues. Our quality commitment supports applications requiring the highest standards in asymmetric catalysis for GMP and non-GMP development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light may degrade catalytic activity.

Specification

Item	Specification
Appearance	Dark green to purple crystalline solid
Identification (IR)	Conforms to structure
Assay (Rh content)	≥ 18.0 % (w/w)
Chiral Purity (Enantiomeric Excess)	≥ 98.0 % ee
Solvent Residues (NMR/HPLC)	Meet ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.