Description

1,4,7,10-Tetraazacyclododecane, 1,4,7,10-Tetrakis(2-Pyridinylmethyl)- CAS NO 185130-32-9 is a sophisticated macrocyclic polyamine ligand, a derivative of cyclen, functionalized with four pyridinylmethyl arms. This structure is critical for its exceptional chelating properties, enabling the formation of highly stable and selective complexes with various metal ions. It is an essential intermediate and reagent for researchers and manufacturers in coordination chemistry, catalysis, and the development of diagnostic and therapeutic agents, particularly in the fields of magnetic resonance imaging (MRI) contrast agents and radiopharmaceuticals.

Application

• MRI Contrast Agent Precursor: Serves as a key ligand for chelating gadolinium (Gd³⁺) and other lanthanide ions to create stable, high-relaxivity contrast agents for medical imaging.
• Radiopharmaceutical Development: Used to complex radioisotopes like copper-64 (⁶⁴Cu) or gallium-68 (⁶⁸Ga) for positron emission tomography (PET) imaging and targeted radiotherapy.
• Catalysis: Acts as a ligand in homogeneous catalysis, where its metal complexes can facilitate various organic transformations and oxidation reactions.
• Chemical Sensing & Separation: Employed in the design of selective sensors and extraction agents for specific metal ions in analytical and environmental chemistry.
• Material Science: Used in the synthesis of functionalized nanomaterials, metal-organic frameworks (MOFs), and luminescent materials.
• Bioconjugation: The functional groups allow for conjugation to antibodies, peptides, or other biomolecules to create targeted imaging or therapeutic probes.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane, 1,4,7,10-Tetrakis(2-Pyridinylmethyl)-
CAS No.	185130-32-9
Molecular Formula	C₃₂H₄₀N₈
Molecular Weight	536.72 g/mol
Synonyms	1,4,7,10-Tetrakis(2-pyridylmethyl)-1,4,7,10-tetraazacyclododecane; DOTAM-Py; Py4C; 1,4,7,10-Tetrakis(2-pyridylmethyl)-cyclen; 2-Pyridylmethyl-cyclen tetrakis; 1,4,7,10-Tetraaza-1,4,7,10-tetrakis(2-pyridylmethyl)cyclododecane; TACN-Py4; Pyridyl-functionalized cyclen ligand
EINECS	Contact for details

Quality Control

Our production of 1,4,7,10-Tetrakis(2-Pyridinylmethyl)-1,4,7,10-tetraazacyclododecane adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, critical for sensitive applications in pharmaceuticals and research. All materials are characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.