Description

Ethyl 6-Methyl-2-Thioxo-4-(p-Tolyl)-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a defined molecular structure. This compound is a critical building block in the synthesis of complex heterocyclic molecules, offering a reliable foundation for research and production. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel dihydropyrimidinone (DHPM) derivatives, a class of compounds with diverse biological activities.
• Medicinal Chemistry Research: Serves as a core scaffold for drug discovery programs targeting various therapeutic areas, including antiviral, antibacterial, and anti-inflammatory agents.
• Organic Synthesis Building Block: Used in multi-step synthetic routes to create complex heterocyclic systems for advanced material science and agrochemical research.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Ethyl 6-Methyl-2-Thioxo-4-(p-Tolyl)-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
CAS No.	185023-34-1
Molecular Formula	C₁₅H₁₈N₂O₂S
Molecular Weight	290.38 g/mol
Synonyms	Ethyl 4-(4-Methylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 4-(p-Tolyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester; 5-Carbethoxy-4-(4-methylphenyl)-6-methyl-3,4-dihydro-2(1H)-pyrimidinethione; Biginelli Reaction Derivative; DHPM Derivative; CAS 185023-34-1
EINECS	Contact for details

Quality Control

Our Ethyl 6-Methyl-2-Thioxo-4-(p-Tolyl)-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.