Description

4-(Trifluoromethyl)-1H,2H,5H,6H,7H-Cyclopenta[B]Pyridin-2-One CAS NO 184375-75-5 is a high-value, fluorinated heterocyclic building block characterized by its cyclopenta[b]pyridin-2-one core and a strategically positioned trifluoromethyl group. This compound is essential for medicinal chemistry and advanced materials research, where its unique structure imparts desirable properties such as enhanced metabolic stability, lipophilicity, and electronic effects. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A critical scaffold for the research and development of new drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory therapies.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the CF3 group improves biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for organic electronic materials, including OLEDs and semiconductors, due to its electron-deficient aromatic system.
• Fluorine Chemistry Building Block: Employed in exploratory synthetic chemistry to introduce the trifluoromethyl moiety into complex molecular architectures.
• Ligand and Catalyst Development: Utilized in the design of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Academic and R&D Laboratories: A key reagent for studying structure-activity relationships (SAR) and novel heterocyclic reaction pathways.

Basic Information

Product Name	4-(Trifluoromethyl)-1H,2H,5H,6H,7H-Cyclopenta[B]Pyridin-2-One
CAS No.	184375-75-5
Molecular Formula	C9H8F3NO
Molecular Weight	203.16 g/mol
Synonyms	4-(Trifluoromethyl)-1H,2H,5H,6H,7H-cyclopenta[b]pyridin-2-one; 4-(Trifluoromethyl)-2,3,5,6,7-pentahydro-1H-cyclopenta[b]pyridin-2-one; 4-Trifluoromethyl-1H,2H,5H,6H,7H-cyclopenta[b]pyridin-2-one; 2H-Cyclopenta[b]pyridin-2-one, 1,5,6,7-tetrahydro-4-(trifluoromethyl)-; 4-(Trifluoromethyl)-1,5,6,7-tetrahydro-2H-cyclopenta[b]pyridin-2-one; 184375-75-5; 4-CF3-Cyclopenta[b]pyridin-2-one
EINECS	Contact for details

Quality Control

Our production of 4-(Trifluoromethyl)-1H,2H,5H,6H,7H-Cyclopenta[B]Pyridin-2-One adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements or regulatory standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.