Description

n-(3,4-Difluorophenyl)-6-Nitro-4-Quinazolinamine is a high-purity, advanced pharmaceutical intermediate with the CAS number 184360-64-3. This compound is a key building block in the synthesis of targeted therapeutic agents, offering critical structural features for drug discovery and development. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the creation of novel kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of targeted kinase inhibitors for oncology and inflammatory disease research.
• Drug Discovery & Development: Serves as a core scaffold for medicinal chemistry programs, enabling structure-activity relationship (SAR) studies.
• Biochemical Research: Used as a reference standard or tool compound in enzymatic assays and biological target validation.
• API Synthesis: Employed in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) under current Good Manufacturing Practice (cGMP) conditions.
• Academic Research: Utilized in university and institutional labs for investigating novel quinazoline-based pharmacophores.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	n-(3,4-Difluorophenyl)-6-Nitro-4-Quinazolinamine
CAS No.	184360-64-3
Molecular Formula	C14H8F2N4O2
Molecular Weight	302.24 g/mol
Synonyms	6-Nitro-N-(3,4-difluorophenyl)-4-quinazolinamine; 4-Quinazolinamine, N-(3,4-difluorophenyl)-6-nitro-; N-(3,4-Difluorophenyl)-6-nitroquinazolin-4-amine; 184360-64-3; 6-Nitro-N-(3,4-difluorophenyl)quinazolin-4-amine; Quinazolinamine, N-(3,4-difluorophenyl)-6-nitro-
EINECS	Contact for details

Quality Control

Our n-(3,4-Difluorophenyl)-6-Nitro-4-Quinazolinamine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) is supplied with each batch, detailing all critical quality attributes. Our quality commitment aligns with the standards required for pharmaceutical R&D and cGMP intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.