Description

(S)-2-Amino-1-(Pyrrolidin-1-Yl)Propane-1-Thione Hydrochloride is a high-purity chiral building block and intermediate of significant interest in advanced organic synthesis. Its value lies in its unique stereochemistry and functional groups, which are critical for constructing complex molecular architectures with specific biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly within medicinal chemistry programs targeting neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the potency and selectivity of lead compounds.
• Asymmetric Synthesis: Serves as a precursor or catalyst ligand in stereoselective reactions to create enantiomerically pure molecules.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Process Chemistry Development: Investigated for scalable synthetic routes in the pilot-scale manufacturing of advanced intermediates.
• Academic Research: Employed in university and institutional labs for methodological development in organic and heterocyclic chemistry.

Basic Information

Product Name	(S)-2-Amino-1-(Pyrrolidin-1-Yl)Propane-1-Thione Hydrochloride
CAS No.	184360-52-9
Molecular Formula	C8H17N3S • HCl
Molecular Weight	223.77 g/mol (Free base: 187.30 g/mol)
Synonyms	(S)-2-Amino-1-(1-pyrrolidinyl)-1-propanethione hydrochloride; (S)-2-Amino-1-pyrrolidin-1-yl-propan-1-thione hydrochloride; (S)-APPT hydrochloride; (S)-1-(1-Pyrrolidinyl)-2-amino-1-propanethione hydrochloride; (S)-1-Pyrrolidin-1-yl-2-amino-propan-1-thione hydrochloride; (S)-α-Aminopropiophenone pyrrolidine thioamide hydrochloride; (S)-2-Amino-1-(pyrrolidin-1-yl)propan-1-thione HCl
EINECS	Contact for details

Quality Control

Our (S)-2-Amino-1-(Pyrrolidin-1-Yl)Propane-1-Thione Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and support your critical R&D work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.