Description

4-(3-Chloro-4-Fluoroanilino)-6-Nitroquinazoline is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound serves as a critical building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is essential for research and development laboratories, process chemists, and manufacturers in the global pharmaceutical and biotechnology sectors focused on innovative drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel small-molecule drugs, especially tyrosine kinase inhibitors (TKIs).
• Oncology Research: Used in the development and study of targeted cancer therapies that interfere with specific signaling pathways involved in tumor growth.
• Chemical Biology: Serves as a scaffold or probe compound for studying enzyme kinetics, protein-ligand interactions, and cellular signaling mechanisms.
• Process Development & Scale-up: Employed in optimizing synthetic routes for the cost-effective and scalable production of active pharmaceutical ingredients (APIs).
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development, validation, and impurity profiling.

Basic Information

Product Name	4-(3-Chloro-4-Fluoroanilino)-6-Nitroquinazoline
CAS No.	184356-50-1
Molecular Formula	C14H8ClFN4O2
Molecular Weight	318.69 g/mol
Synonyms	4-[(3-Chloro-4-fluorophenyl)amino]-6-nitroquinazoline; 6-Nitro-4-((3-chloro-4-fluorophenyl)amino)quinazoline; 4-(3-Chloro-4-fluoroanilino)-6-nitro-quinazoline; Quinazoline, 4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-; 184356-50-1; 4-(3-Chloro-4-fluoroanilino)-6-nitroquinazoline; 4-(3-Chloro-4-fluoro-phenylamino)-6-nitro-quinazoline
EINECS	Contact for details

Quality Control

Every batch of 4-(3-Chloro-4-Fluoroanilino)-6-Nitroquinazoline is manufactured under strict quality management systems and undergoes comprehensive analytical testing. Our products are validated to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain product integrity.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 98.5%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.