Description

L-Proline, 4-(Aminooxy)-, (4S)- (9Ci) is a specialized, non-proteinogenic amino acid derivative of L-proline, featuring a unique aminooxy functional group at the 4-position. This structural modification makes it a valuable chiral building block and a key intermediate in the synthesis of complex bioactive molecules, particularly in pharmaceutical research and development. It is essential for scientists and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, stereochemically defined intermediates for drug discovery, bioconjugation, and catalyst development.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, including enzyme inhibitors and peptide mimetics.
• Bioconjugation Reagent: Used in the site-specific modification of proteins, antibodies, and other biomolecules via oxime ligation chemistry.
• Chemical Biology Research: Serves as a tool compound for studying enzyme mechanisms and developing activity-based probes.
• Agrochemical Synthesis: An intermediate in the production of advanced, chiral active ingredients for crop protection.
• Catalyst and Ligand Development: Used to create novel chiral catalysts and ligands for asymmetric synthesis.
• Peptidomimetic Design: Incorporated into peptide analogs to enhance metabolic stability and biological activity.

Basic Information

Item	Details
Product Name	L-Proline, 4-(Aminooxy)-, (4S)- (9Ci)
CAS No.	183994-91-4
Molecular Formula	C5H10N2O3
Molecular Weight	146.15 g/mol
Synonyms	(4S)-4-(Aminooxy)-L-proline; (S)-4-(Aminooxy)pyrrolidine-2-carboxylic acid; 4-Aminooxy-L-proline; 4-(Aminooxy)-(S)-proline; 4-Hydroxyamino-L-proline; Aminooxyproline; O-Aminohydroxy-L-proline; L-4-(Aminooxy)proline
EINECS	Contact for details

Quality Control

We supply L-Proline, 4-(Aminooxy)-, (4S)- (9Ci) under a strict quality management system. Each batch is characterized and tested to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, and comprehensive Certificates of Analysis (COA) detailing purity (by HPLC), chiral purity, and impurity profiles are available upon request. We adhere to cGMP principles for pharmaceutical-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. For long-term storage, consider storing under an inert gas (argon or nitrogen) due to its sensitivity to oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.