Description

2-(Fmoc-Amino)-5-Bromobenzoic Acid is a high-purity, protected amino acid derivative designed for advanced organic synthesis. This compound is a critical building block in the solid-phase peptide synthesis (SPPS) workflow, where its Fmoc-protected amino group and reactive carboxylic acid moiety enable precise chain elongation. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and other bioactive molecules. The bromine substituent offers a versatile handle for further functionalization via cross-coupling reactions, expanding its utility in medicinal chemistry and materials science.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid building block for the automated synthesis of complex peptides and small proteins.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of peptide-based therapeutics, diagnostic agents, and targeted drug conjugates.
• Combinatorial Chemistry: Serves as a versatile monomer for creating diverse chemical libraries for high-throughput screening.
• Bioconjugation: The carboxylic acid group facilitates coupling to amines on proteins, antibodies, or other biomolecules for labeling and linker attachment.
• Organic Synthesis Intermediate: The aromatic bromine atom allows for further derivatization via palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Materials Science Research: Potential use in synthesizing functionalized polymers or organic frameworks with specific electronic or photonic properties.

Basic Information

Product Name	2-(Fmoc-Amino)-5-Bromobenzoic Acid
CAS No.	183871-04-7
Molecular Formula	C22H16BrNO4
Molecular Weight	438.27 g/mol
Synonyms	5-Bromo-2-[(9H-fluoren-9-ylmethoxy)carbonylamino]benzoic Acid; Fmoc-2-Amino-5-bromobenzoic Acid; 2-Amino-5-bromobenzoic Acid N-Fmoc derivative; 2-(9-Fluorenylmethoxycarbonylamino)-5-bromobenzoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-bromoanthranilic Acid; 5-Bromo-N-Fmoc-anthranilic Acid; Fmoc-5-Bromoanthranilic Acid; 2-[(Fmoc)amino]-5-bromobenzoic Acid
EINECS	Contact for details

Quality Control

Our 2-(Fmoc-Amino)-5-Bromobenzoic Acid is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive research and development applications. Each batch is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry to verify identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.