Description

4-Chloro-7-(2-Chloro-Ethoxy)-6-(2-Methoxy-Ethoxy)-Quinazoline is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This quinazoline derivative serves as a critical building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is essential for research and development laboratories, process chemists, and manufacturers in the global pharmaceutical and biotechnology sectors who require reliable, high-quality raw materials for complex organic synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially tyrosine kinase inhibitors (TKIs).
• Oncology Research: Used in the development and production of targeted cancer therapies that interfere with specific cellular signaling pathways.
• Chemical Synthesis: Serves as a versatile scaffold for medicinal chemistry, enabling the exploration of structure-activity relationships (SAR).
• Process Development & Scale-up: Employed in optimizing synthetic routes from laboratory scale to commercial manufacturing under cGMP conditions.
• Reference Standard: Utilized as an analytical standard for quality control and regulatory submissions in drug development pipelines.

Basic Information

Product Name	4-Chloro-7-(2-Chloro-Ethoxy)-6-(2-Methoxy-Ethoxy)-Quinazoline
CAS No.	183322-20-5
Molecular Formula	C₁₃H₁₄Cl₂N₂O₃
Molecular Weight	317.17 g/mol
Synonyms	4-Chloro-7-(2-chloroethoxy)-6-(2-methoxyethoxy)quinazoline; 6-(2-Methoxyethoxy)-7-(2-chloroethoxy)-4-chloroquinazoline; 183322-20-5; 4-Chloro-6,7-bis(2-alkoxyethoxy)quinazoline derivative; Quinazoline, 4-chloro-7-(2-chloroethoxy)-6-(2-methoxyethoxy)-; EGFR Inhibitor Intermediate; Gefitinib/Erlotinib related intermediate
EINECS	Contact for details

Quality Control

Our 4-Chloro-7-(2-Chloro-Ethoxy)-6-(2-Methoxy-Ethoxy)-Quinazoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, supporting compliance with cGMP and other relevant regulatory frameworks for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat and incompatible materials. Due to its light-sensitive nature, handling should be conducted under appropriate conditions to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.