Description

4-Chloro-6-(2-Chloro-Ethoxy)-7-(2-Methoxy-Ethoxy)-Quinazoline is a high-purity, functionalized quinazoline derivative, a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of targeted pharmaceutical agents, particularly kinase inhibitors. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel therapeutic compounds for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of tyrosine kinase inhibitors and other small-molecule drug candidates.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry programs, enabling structure-activity relationship (SAR) studies.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step manufacturing process of complex active drug substances.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme inhibition and cellular signaling pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	4-Chloro-6-(2-Chloro-Ethoxy)-7-(2-Methoxy-Ethoxy)-Quinazoline
CAS No.	183322-19-2
Molecular Formula	C₁₃H₁₄Cl₂N₂O₃
Molecular Weight	317.17 g/mol
Synonyms	4-Chloro-6-(2-chloroethoxy)-7-(2-methoxyethoxy)quinazoline; 7-(2-Methoxyethoxy)-4-chloro-6-(2-chloroethoxy)quinazoline; 4-Chloro-6,7-bis(2-chloroethoxy)quinazoline derivative; Quinazoline, 4-chloro-6-(2-chloroethoxy)-7-(2-methoxyethoxy)-; 183322-19-2; Gefitinib Intermediate; EGFR Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-(2-Chloro-Ethoxy)-7-(2-Methoxy-Ethoxy)-Quinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.