Description

4-[(3-Ethynylphenyl)Amino]-6,7-Bis(2-Hydroxyethoxy)Quinazoline is a high-purity, synthetically derived quinazoline derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical pharmacological reference standard and a key synthetic intermediate for the development of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in oncology and targeted therapy discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel tyrosine kinase inhibitors and other targeted cancer therapeutics.
• Biochemical Research: Used as a reference compound in enzymatic assays and studies of signal transduction pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Preclinical Development: Employed in in vitro and in vivo studies to evaluate pharmacokinetic and pharmacodynamic properties.
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and drug design.
• Process Chemistry: Acts as a starting material or intermediate in the scale-up and optimization of active pharmaceutical ingredient (API) manufacturing processes.

Basic Information

Product Name	4-[(3-Ethynylphenyl)Amino]-6,7-Bis(2-Hydroxyethoxy)Quinazoline
CAS No.	183321-84-8
Molecular Formula	C20H19N3O4
Molecular Weight	365.38 g/mol
Synonyms	6,7-Bis(2-hydroxyethoxy)-4-[(3-ethynylphenyl)amino]quinazoline; 4-(3-Ethynylphenylamino)-6,7-bis(2-hydroxyethoxy)quinazoline; 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-hydroxyethoxy)quinazoline; 183321-84-8; EGFR Inhibitor Intermediate; Quinazoline Derivative 183321-84-8; CP-724714 Intermediate (related compound)
EINECS	Contact for details

Quality Control

Our 4-[(3-Ethynylphenyl)Amino]-6,7-Bis(2-Hydroxyethoxy)Quinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards expected for pharmaceutical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.