Description

2-(Boc-Amino)-2-(1,2,3,4-Tetrahydronaphthalen-1-Yl)Acetic Acid is a protected amino acid derivative featuring a Boc (tert-butoxycarbonyl) group and a 1,2,3,4-tetrahydronaphthalene (tetralin) moiety. This compound is a critical chiral building block in organic synthesis, valued for its role in constructing complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptidomimetics, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) targets.
• Peptide Synthesis: Serves as a protected amino acid component in solid-phase and solution-phase peptide synthesis to introduce the tetralin-based side chain.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to explore new chemical entities.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric transformations due to its inherent chirality.
• Chemical Biology: Can be incorporated into molecular probes or tools for studying biological processes and protein interactions.
• Custom Synthesis: A foundational block for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	2-(Boc-Amino)-2-(1,2,3,4-Tetrahydronaphthalen-1-Yl)Acetic Acid
CAS No.	182291-95-8
Molecular Formula	C₁₇H₂₃NO₄
Molecular Weight	305.37 g/mol
Synonyms	N-Boc-1-amino-1,2,3,4-tetrahydronaphthalene-1-acetic acid; (1-(Carboxymethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamic acid tert-butyl ester; 2-[(tert-Butoxycarbonyl)amino]-2-(1,2,3,4-tetrahydronaphthalen-1-yl)acetic acid; Boc-1-Amino-1,2,3,4-tetrahydronaphthalene-1-acetic Acid; N-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydro-1-naphthalenylglycine; 2-(tert-Butoxycarbonylamino)-2-(1,2,3,4-tetrahydro-1-naphthyl)acetic acid
EINECS	Contact for details

Quality Control

Our production of 2-(Boc-Amino)-2-(1,2,3,4-Tetrahydronaphthalen-1-Yl)Acetic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure high chemical and enantiomeric purity suitable for advanced research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.