Description

8-[(S)-Hydroxy[4-(Phenylmethoxy)Phenyl]Methyl]-1,4-Dioxaspiro[4.5]Decane-8-Carboxylic Acid Ethyl Ester is a high-purity chiral intermediate featuring a complex spirocyclic and aromatic structure. This compound is of critical importance in the synthesis of advanced pharmaceutical active ingredients, particularly those targeting central nervous system and cardiovascular pathways. It is primarily required by R&D laboratories and production facilities in the pharmaceutical and fine chemical industries for the development and scalable manufacture of novel therapeutic agents.

Application

• Key chiral building block for the synthesis of complex pharmaceutical molecules.
• Advanced intermediate in the research and development of new chemical entities (NCEs).
• Precursor for active pharmaceutical ingredients (APIs) with spirocyclic architectures.
• Use in asymmetric synthesis and medicinal chemistry programs.
• Process development and scale-up manufacturing for clinical trial material.
• Reference standard for analytical method development and quality control.

Basic Information

Product Name	8-[(S)-Hydroxy[4-(Phenylmethoxy)Phenyl]Methyl]-1,4-Dioxaspiro[4.5]Decane-8-Carboxylic Acid Ethyl Ester
CAS No.	182227-19-6
Molecular Formula	C26H32O6
Molecular Weight	440.53 g/mol
Synonyms	Ethyl (8S)-8-[hydroxy(4-phenylmethoxyphenyl)methyl]-1,4-dioxaspiro[4.5]decane-8-carboxylate; (S)-8-[Hydroxy(4-benzyloxyphenyl)methyl]-1,4-dioxaspiro[4.5]decane-8-carboxylic acid ethyl ester; 1,4-Dioxaspiro[4.5]decane-8-carboxylic acid, 8-[(S)-hydroxy[4-(phenylmethoxy)phenyl]methyl]-, ethyl ester; CAS 182227-19-6; Benzeneethanol, α-[(1S)-1-(ethoxycarbonyl)-1,4-dioxaspiro[4.5]dec-8-yl]-4-(phenylmethoxy)-; (S)-Ethyl 8-(hydroxy(4-(benzyloxy)phenyl)methyl)-1,4-dioxaspiro[4.5]decane-8-carboxylate
EINECS	Contact for details

Quality Control

Our pharmaceutical-grade intermediate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) with full traceability are provided, and we support customer audits and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.