Description

2-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical Fmoc-protected building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of peptides containing the tetrahydroisoquinoline carboxylic acid (Tic) scaffold.
• Pharmaceutical Intermediate: For the research and development of drug candidates targeting neurological disorders, cardiovascular diseases, and oncology.
• Peptidomimetic Design: Used to incorporate constrained, non-natural amino acid structures into peptide backbones to enhance stability, bioavailability, and receptor selectivity.
• Bioconjugation and Probe Development: Serves as a precursor for creating labeled peptides or affinity tags used in biochemical assays and imaging studies.
• Academic and Industrial R&D: A vital reagent in medicinal chemistry laboratories for exploring structure-activity relationships (SAR) in peptide-based projects.

Basic Information

Product Name	2-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid
CAS No.	182161-83-7
Molecular Formula	C26H21NO5
Molecular Weight	427.45 g/mol
Synonyms	Fmoc-Tic-OH; (S)-1-Fmoc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; Fmoc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; Fmoc-3,4-dihydro-1H-isoquinoline-3-carboxylic acid; N-Fmoc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (S)-N-Fmoc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of our Fmoc-Tic-OH is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming identity, purity, and conformity to customer specifications. Our quality commitment ensures material integrity for sensitive applications in GMP-grade peptide synthesis and advanced research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.