Description

1-(7-Bromo-3,4-Dihydro-1H-Isoquinolin-2-Yl)-2,2,2-Trifluoroethanone is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated isoquinoline and trifluoroacetyl structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic agents.
• Organic Synthesis Reagent: Serves as a versatile precursor for introducing the 7-bromo-3,4-dihydroisoquinoline moiety into more complex molecular architectures.
• Chemical Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Tool Compound: Utilized in biochemical assays to study enzyme inhibition and receptor binding activities.
• Academic & Industrial R&D: Essential for research in universities and corporate R&D centers exploring new chemical entities (NCEs).

Basic Information

Product Name	1-(7-Bromo-3,4-Dihydro-1H-Isoquinolin-2-Yl)-2,2,2-Trifluoroethanone
CAS No.	181514-35-2
Molecular Formula	C₁₁H₉BrF₃NO
Molecular Weight	308.10 g/mol
Synonyms	2,2,2-Trifluoro-1-(7-bromo-1,2,3,4-tetrahydroisoquinolin-2-yl)ethanone; 1-(7-Bromo-3,4-dihydro-1H-isoquinolin-2-yl)-2,2,2-trifluoroethanone; 7-Bromo-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline; 2-(Trifluoroacetyl)-7-bromo-1,2,3,4-tetrahydroisoquinoline; 7-Bromo-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline; 181514-35-2; 1-(7-Bromo-1,2,3,4-tetrahydroisoquinolin-2-yl)-2,2,2-trifluoroethanone
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Quality Control

Our 1-(7-Bromo-3,4-Dihydro-1H-Isoquinolin-2-Yl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles suitable for pharmaceutical R&D applications, ensuring reliable supply and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in its original packaging to protect from moisture. Store away from incompatible materials such as strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.