Description

D-Alanine, n-Nitro- (9Ci) is a specialized, non-natural amino acid derivative characterized by its chiral D-configuration and a nitro functional group. This compound is a crucial chiral building block and intermediate in advanced organic synthesis and pharmaceutical research. It is primarily utilized by research institutions and industrial R&D departments focused on developing novel peptides, enzyme inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a nitro-substituted D-alanine residue, modifying peptide stability, activity, or binding properties.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate enzyme mechanisms, specificity, and kinetics, especially with enzymes that process D-amino acids.
• Chemical Biology Probe Development: Acts as a building block for creating molecular probes to study biological pathways, protein-protein interactions, and cellular processes.
• Agrochemical Research: Investigated as a potential intermediate in the synthesis of novel chiral herbicides or plant growth regulators.
• Material Science: Explored for the synthesis of specialized polymers or functional materials where chiral nitro compounds can impart unique optical or electronic properties.

Basic Information

Product Name	D-Alanine, n-Nitro- (9Ci)
CAS No.	181182-86-5
Molecular Formula	C3H6N2O4
Molecular Weight	134.09 g/mol
Synonyms	(R)-2-Amino-3-nitropropanoic acid; D-2-Amino-3-nitropropionic acid; D-3-Nitroalanine; (R)-3-Nitroalanine; D-β-Nitroalanine; D-Alanine, 3-nitro-; (R)-2-Amino-3-nitro-propanoic acid; D-α-Amino-β-nitropropionic acid
EINECS	Contact for details

Quality Control

Our D-Alanine, n-Nitro- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure high chemical and optical purity suitable for demanding research applications. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.