Description

4-Maleimidobutyric Acid Hydrazide is a heterobifunctional crosslinking reagent featuring a maleimide group and a hydrazide group. This molecular structure is critical for creating stable, site-specific conjugations between carbonyl-containing molecules and thiol-containing molecules under mild conditions. It is an essential tool for researchers and manufacturers in the bioconjugation and pharmaceutical development sectors, enabling the creation of advanced drug delivery systems, diagnostic assays, and biopharmaceuticals.

Application

• Bioconjugation and Protein Labeling: Site-specific conjugation of antibodies, peptides, or proteins with drugs, toxins, fluorophores, or enzymes.
• Antibody-Drug Conjugate (ADC) Development: A key linker chemistry for attaching cytotoxic payloads to monoclonal antibodies via oxidized carbohydrate chains (glycans).
• Diagnostic Reagent Manufacturing: Preparation of enzyme-labeled antibodies or antigens for ELISA and other immunoassay kits.
• Polymer and Biomaterial Modification: Functionalization of polymers, hydrogels, or surfaces with bioactive molecules for tissue engineering and biosensor applications.
• Glycoprotein Analysis and Modification: Selective labeling or immobilization of glycoproteins through their oxidized sugar moieties.
• Liposome and Nanoparticle Functionalization: Attaching targeting ligands (e.g., antibodies, peptides) to the surface of drug delivery carriers.

Basic Information

Product Name	4-Maleimidobutyric Acid Hydrazide
CAS No.	181148-01-6
Molecular Formula	C9H11N3O4
Molecular Weight	225.20 g/mol
Synonyms	4-Maleimidobutyric hydrazide; Maleimidobutyric acid hydrazide; MBH; 4-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)butanoic hydrazide; 1-(3-Hydrazinyl-3-oxopropyl)-1H-pyrrole-2,5-dione; GMBS Hydrazide; γ-Maleimidobutyric acid hydrazide; N-(3-Hydrazinyl-3-oxopropyl)maleimide
EINECS	Contact for details

Quality Control

Our 4-Maleimidobutyric Acid Hydrazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and biopharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.